However, it has now been shown that many tumour types are more heavily dependent than normal tissues on the activity of key transcriptional drivers, for example RUNX1 in acute lymphoblastic leukaemia (ALL) [10] and N-myc in neuroblastoma [10], and also on super-enhancer driven transcription [10–13]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.