IFNAR1 and lung carcinoma: While various aberrations in the type I interferon signalling pathway are described for many human tumour cell lines,31,32 interferon insensitivity is often lacking in murine models of cancer.14,17,33 To generate a tumour system with limited antiviral effect of type I interferon signalling that more closely mimics the condition found in many human cancers, the subunit 1 of the heterodimeric interferon type I receptor complex (IFNAR1) was knocked-out in murine LLC1 lung cancer cells.