Of the 1,743 predicted targeted genes, only 626 were unique genes, and IGF1R, KRAS, RUNX1T1 and SLC9A8 were regulated by 3 miRNAs.The most frequently enriched pathways were categorized under biological processes connected with cancer (renal cell carcinoma, melanoma, etc.), cardiovascular diseases (dilated cardiomyopathy, hypertrophic cardiomyopathy, etc.), and signalling (sphingolipid signalling, adrenergic signalling of cardiomyocytes, etc.)(see e-Table 6 and e-Fig. 6). The gene discussed is KRAS; the disease is melanoma.