Moreover, in a recent study, Josefsson et al., showed that tumors from NHL patients were enriched in CD4+ and CD8+ TEM cells expressing both PD-1 and TIGIT and exhibiting reduced effector functions in immunosuppressive tumor microenvironment, but normal cytokine production upon in vitro culture in absence of their ligands39. Here, CD4 is linked to non-Hodgkin lymphoma.