CRP and infection: Severe complicated CDI was associated with male gender (p = 0.028), higher APACHE II score (p < 0.001), onset of CDI in the intensive care unit setting (p = 0.001), higher C-reactive protein level (p = 0.001), prior carbapenem usage in the past 90 days (p = 0.036), concurrent H2RA use during CDI episode (p = 0.042) and concurrent antibiotic use for treating infections other than CDI (p = 0.004).