Fitting these variables with Charlson’s comorbidity score into the multivariable logistic regression model, high APACHE II score (adjusted OR [aOR] 1.112, 95% CI 1.014–1.219; p = 0.024), high C-reactive protein (aOR 1.011; 95% CI 1.004–1.019; p = 0.004) and prior carbapenem usage in the past 90 days (aOR 3.259; 95% CI 1.105–9.609; p = 0.032) were identified as independent risk factors of severe and severe complicated CDI (Table 2)13. This evidence concerns the gene CRP and clostridium difficile infection.