GWAS signals close to the latter two inversions are consistent with their effect on genes, involving type 1 and 2 diabetes, pancreatic cancer, insulin secretion, and cholesterol and triglyceride levels for HsInv0030, and glaucoma and optic disc and nerve characteristics for HsInv0347, which is associated to the expression of c14orf39 (SIX6OS1) and SIX6, related to eye development. Here, SIX6 is linked to pancreatic neoplasm.