PRDM14, a transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in pancreatic cancer tissues, and the inhibition of PRDM14 reduces sphere formation, stemness, stem cell markers, tumorigenesis, and metastasis in mice by upregulation of different miRNAs such as miR-125a-3p. Here, PRDM14 is linked to pancreatic neoplasm.