PRLR and neoplasm: Further, inhibition of miR-31 in MMTV-PyVT mice lead to reduce tumor growth, decrease in number of BCSCs, and reduced tumor-initiating potential and metastasis by modulating a number of signaling pathways, including Prlr/Stat5, TGFβ and Wnt/β-catenin, suggesting that miR-31 is critical for BCSC stemness and associated tumorigenesis [88].