CD44 and neoplasm: Genetic mapping analysis suggests that a particular location on chromosome 8p, a critical genetic alteration related to PCa initiation and metastasis, is directly associated with the downregulation of miR-383-is, which plays a critical role in PCa development via regulating CD44, a ubiquitous marker of PCaSCs, and the forced upregulation of miR-383 inhibited tumor-initiating capacity of PCaSCs and metastasis, suggesting that the restoration of miR-383 at the chr8p22 region may be an effective therapeutic modality against PCa [163].