Self-renewal potential of cancer stem cells is a feature which has huge impact on oncogenicity as it poses great therapeutic challenges, and it has been observed that miRNAs are critical in the self-renewal feature of CSCs via modulating expression and functioning of the signaling molecules related to a number of pathways such as JAK/STAT, TGFβ, PI3K/Akt, and MAPK [66]. This evidence concerns the gene TGFB1 and cancer.