miR-612 negatively regulated stem cell-like properties and tumor metastasis of HCC as miR-612 inversely modulates the mRNA and protein levels of epithelial cell adhesion molecule as well as CD133 negatively regulates the numbers and sizes of tumor spheres, directly inhibits the protein level of Sp1, and subsequently reduces transcription activity of Nanog. The gene discussed is PROM1; the disease is neoplasm.