STAT3 and hepatocellular carcinoma: Further, it has been shown that miR-500a-3p promotes the CSC features by targeting the negative regulators of SOCS2, SOCS4, and PTPN11 of STAT3, resulting in constitutive STAT3 activation as miR-500a-3p-induced stemness features reversed STAT3 inhibitors Stattic and S3I-201 in HCC cells [110].