It has been observed that miR-199a-3p is underexpressed in CD44+ PCaSCs and induced upregulation of miR-199a-3p in PCaSCs and that primary cancer cells suppressed growth, proliferation, and cancer-initiating potential of PCaSCs and tumors via targeting CD44 directly in addition to various other signaling molecules associated with cancer development like c-MYC, cyclin D1 (CCND1), and EGFR, suggesting that the attenuation of deregulated loss of miR-199a-3p may be viable for PCa therapy [164]. The gene discussed is EGFR; the disease is cancer.