Further another investigation by Jin et al. revealed the effect of miR-195-5p on maintaining CRCSCs as they found that expression of SOX2 and CD133 stem-cell markers are inhibited by miR-195-5p in the SW620 colon cancer cell line, while miR-195-5p silencing stimulated SOX2 and CD133 expression in the HT29 cell line, suggesting that miR-195-5p inhibits stemness features of colorectal CSCs. The gene discussed is PROM1; the disease is malignant colon neoplasm.