Deregulated overexpression of miR-218 detected in PCa specimens including spheroids has been shown to upregulate the expansion and stemness of PCaSCs and markers like OCT4, SOX2, NANOG, CD44, KLF4, c-MYC, and metalloproteases via targeting activation of Wnt signaling pathway by suppressing GSK3β and SFRP1 [98]. This evidence concerns the gene CD44 and posterior cortical atrophy.