Further, knockdown of Lin28A and Lin28B has been shown to markedly reduce the expression of CSC markers, like Nanog, Sox2, POU5F1, KLF4, and BMI-1, along with reduced PCaSCs, suggesting that Lin28A and Lin28B targeting could selectively remove CSCs form PCa [165]. This evidence concerns the gene POU5F1 and posterior cortical atrophy.