In another study, Yu et al. demonstrated that knockdown of miR-145 increased the ability of sphere formation and ALDH1+/CD44+ percentage in ALDH1−/CD44− oral cancer cells and elevated the rate of cell proliferation, tumor growth, and invasion, suggesting that miR-145 suppression causes head and neck cancer cells to gain CSCs properties. The gene discussed is CD44; the disease is lip and oral cavity carcinoma.