Further, they also elucidated the underlying mechanism of miR-372/373-induced stemness and revealed that activated Nanog and Hedgehog signaling pathways are critically associated with the development and function of stem cells while the functioning of NFκB, mitogen-activated protein kinase (MAPK)/Erk, and VDR signaling mechanisms vital for differentiation was inhibited by miR-372/373, which suggests that miR-372/373 upregulates CRC stemness features via acting on various signaling mechanisms associated with the regulation of stemness and differentiation [65]. This evidence concerns the gene EPHB2 and colorectal carcinoma.