In keeping with these results, loss of specific tumor suppressors, such as promyelocytic leukemia protein (PML) or tuberous sclerosis proteins 1 and 2 (TSC1 and TSC2), has been shown to promote HIF-1α expression through suppression of hypoxia-induced inhibition of mTOR [2, 4]. The gene discussed is HIF1A; the disease is neoplasm.