We have previously shown that zebrafish Cxcr3.2 is a functional homolog of human CXCR3, required for macrophage migration toward the infection‐inducible Cxcl11aa chemokine ligand.29 Because macrophages also express the paralog Cxcr3.3, we set out to investigate the interaction between these 2 Cxcr3 family receptors. The gene discussed is CXCR3; the disease is infection.