Significance of salivary biomarkers are widely reported; an elevated level of CA 15 and Her2/neu and low levels of p53 are reported for breast cancer [12], elevated CA 125 is reported in patients with ovarian cancer [13], salivary leptin is expressed in a higher quantity in salivary gland tumors compared to healthy parotid tissue [14]. The gene discussed is ERBB2; the disease is ovarian cancer.