It has also been observed that activated platelets of patients with SCD produce thrombospondin and members of cytokine/chemokine network particularly IL-1 and CXCL8 that contribute to the starting of vascular occlusions and IL-1 activates the vascular endothelium as well [24–26]. The gene discussed is CXCL8; the disease is Schnyder corneal dystrophy.