The FLT3-ITD and FLT3-TKD (tyrosine kinase domain) mutations are biomarkers for high risk AML and are associated with drug resistance and high risk of relapse [14, 15], particularly in those patients with wild-type NPM1 and high alleilic ratio of FLT3-ITD. The gene discussed is FLT3; the disease is acute myeloid leukemia.