ALOX12 and polyp of large intestine: Additionally, colorectal polyp and tumor tissue show progressively more intense and diffuse staining for ALOX5 and ALOX12 compared with surrounding tissue, indicating that ALOX5 and ALOX12 expression is activated early in colorectal cancer development and as the degree of malignancy increases, ALOX5 and ALOX12 expression becomes more intense and diffuse in distribution.