Transwell invasion assay results manifested that the invasion rate of MDA-MB-231 and MCF-7 were highest when stimulated with 10 ng/mL IL-22 (Figure 1A).To investigate whether IL-22 facilitated breast cancer cells invasion by increasing EMT, we assessed the levels of E-cadherin and Vimentin with and without 10 ng/mL IL-22 stimulation with time gradient. This evidence concerns the gene CDH1 and breast carcinoma.