HPGDS and glioma: However, the development of cerebral glioma can only be partly explained by these gene findings, because glioma is a complex tumor, and its development may be associated with susceptibility to multiple genes as well as environmental factors.GST is known to catalyze the detoxification of reactive electrophilic compounds, such as cytotoxic drugs, and GSTs are a large family of cytosolic phase II xenobiotic metabolizing enzymes 45, 46.