As shown in Figures 5A and 5B, overexpression of KCNQ1DN in RCC cells significantly reduced c-Myc expression at transcriptional and translational levels (Figures 5A), while knockdown of KCNQ1DN remarkably elevated c-Myc expression at mRNA and protein levels (Figure 5B). This evidence concerns the gene MYC and renal cell carcinoma.