As previously reported, the aberrant expression of Wnt3a was also found in several human malignancies, including glioblastoma 16, 17, mammary adenocarcinoma 18, 19, colon carcinoma 20, lung cancer 21, prostate cancer 22, malignant mesothelioma 23, esophageal squamous cell carcinoma 24, hepatocellular carcinoma 25-27, and melanoma 28. This evidence concerns the gene WNT3A and Familial prostate cancer.