Indeed, several studies on cancer-derived myofibroblast secretome observed an increase in the production and activation of MMP-1, -2, and -3, which may contribute to the remodeling of the cancer cell microenvironment and therefore to cell migration 52, as well as proteins associated with invasion and metastasis, or that act in the protection of cells against injuries caused by reactive oxygen species 38, 53. Here, MMP1 is linked to cancer.