We found that blocking the expression of TGFβ1 receptor or Smad2 in MSCs could down-regulate the tumor growth promoting effect of MSCs, and significantly down-regulate the expression of TGFβ1, EGF, FAPa and MMP9, which were closely related to the activation and remodeling of tumor interstitial microenvironment. Here, TGFB1 is linked to neoplasm.