CD68 and metastatic malignant neoplasm in the lymph nodes: In our data (Table 1), high numbers of CD163- and CD68-positive TAMs were both significantly associated with lymph nodes metastasis (CD68, P = 0.003; CD163, P < 0.001), high Ki67 (CD68, P = 0.026; CD163, P < 0.001), poor histological grade (CD68, P < 0.001; CD163, P < 0.001) and hormonal receptor negativity (CD68, P < 0.001; CD163, P < 0.001), while a high number of CD163 TAMs was correlated with lymph node metastasis (CD68, P = 0.07; CD163, P = 0.022).