We found that CD68 and CD163 double-positive macrophages were more likely to be distributed in tumors with lymph node metastasis (P < 0.001) and had high histological grade (P < 0.001) and Ki67 index (P < 0.001) as well as negative HR expression (P < 0.001). Here, CD68 is linked to metastatic malignant neoplasm in the lymph nodes.