TLR4 and neoplasm: In this situation, an attenuated S. typhimurium was engineered to express a Toll-like receptor (TLR) 5 agonist Vibrio vulnificus flagellin B protein (FlaB), leading to the recognition of lipopolysaccharide on the surface of the S. typhimurium and triggering an immune response inside the tumour; the efficacy was stronger than with a single TLR4 or TLR5 agonist 74.