It was reported that the aqueous extract of Wu-Ling-Zhi could significantly prolong the survival time of mice with incomplete cerebral ischemia, reduce the brain water content, brain index and malondialdehyde (MDA) level, and increase superoxide dismutase (SOD) activity in rats, indicating that Wu-Ling-Zhi has good protective effect against cerebral ischemia [27]. This evidence concerns the gene SOD1 and Cerebral ischemia.