Among the factors mediating the link between exercise and low cancer risk is the modulation of certain proinflammatory mediators, including tumor necrosis factor (TNF)-alpha, monocyte chemoattractant protein 1, plasminogen activator inhibitor-1, IκB kinase, and NF-kB, and other growth factors and hormones, including adiponectin and interleukin (IL)-10 [16]. The gene discussed is TNF; the disease is cancer.