However, several other parameters such as p53 expression, ki - 67, loss of E cadherin, CK 20 and FGFR3 mutations have been implicated as indicators of progression and recurrence of the tumor.1 Bladder tumors have a high rate of recurrence and progression, thus, prognostic outcome for urothelial carcinoma remains unpredictable, demanding validation of important markers . The gene discussed is FGFR3; the disease is urothelial carcinoma.