TPX2 and clear cell renal carcinoma: Due to its important role in microtubule assembly and mitosis, TPX2 has been found to be over expressed in various human cancers, for instance clear renal cell carcinoma [58], esophageal carcinoma [59], hepatocellular carcinoma (HCC) [52, 60], gastric cancer [61], bladder carcinoma [62] and so on.