The result revealed that both TOP2A and TPX2 expressed much higher in cancers (both LUAD and LUSC) comparing to normal lung tissues (Fig. 7d, f), and Pearson correlation analysis results showed that TOP2A expression was highly similar to TPX2, R = 0.59, 0.79 in LUAD and LUSC respectively (Fig. 7e, g). Here, TOP2A is linked to cancer.