As shown in Table 1, high CD47 expression had a significant association with advanced TNM stage (χ2 = 11.249, P = 0.004), histological grade (χ2 = 10.825, P = 0.004), ER status (χ2 = 5.139, P = 0.023), PR status (χ2 = 9.117, P = 0.003) and recurrence (χ2 = 3.957, P = 0.047), indicating that CD47 may be one of the prognostic factors of breast cancer. This evidence concerns the gene ESR1 and breast cancer.