Since CD47 on the surface of tumor cells binds to the receptor SIRP-α on the macrophages to inhibit normal phagocytosis [12], the anti-phagocytosis effect based on CD47/SIRP-α may be enhanced when CD47 expression is up-regulated and macrophage density is increased, thus affecting the prognosis of breast cancer. The gene discussed is CD47; the disease is breast carcinoma.