Therefore, this study was conducted to assess the renopreventive effect of enalapril and paricalcitol on streptozotocin (STZ)-induced nephropathy and try to elucidate the roles of renal oxidative stress, antioxidant defense system, inflammation and apoptosis through scrutinizing the effects on the renal LPO and antioxidant defense markers as well as the renal expressions of tumor necrosis factor-α (TNF-α), caspase-3, B cell lymphoma-2 (Bcl-2) and protein 53 (p53). This evidence concerns the gene TP53 and Nephropathy.