Dexamethasone induces IR by altering the insulin signaling pathway by inhibiting phosphatidylinositol-3-kinase (PI3K) and serine/threonine protein kinase (Akt), thus preventing the translocation of GLUT4 to the cell surface, which leads to glucose intolerance (a decrease in its consumption)27,28. This evidence concerns the gene SLC2A4 and Glucose intolerance.