Dexamethasone induces IR by altering the insulin signaling pathway by inhibiting phosphatidylinositol-3-kinase (PI3K) and serine/threonine protein kinase (Akt), thus preventing the translocation of GLUT4 to the cell surface, which leads to glucose intolerance (a decrease in its consumption)27,28. The gene discussed is INS; the disease is Glucose intolerance.