SACK1A and familial pancreatic carcinoma: To test this hypothesis, lentiviral constructs expressing two different short hairpin RNA (shRNA) targeting FAM83A (shA2, shA6) or a control shRNA (shGreen Fluorescent Protein/shGFP) were used to knockdown FAM83A in pancreatic cancer cell lines (HPAC, Panc04.03, Panc05.04, Panc08.13).