MKI67 and neoplasm: Moreover, when a Cox multivariate regression model was applied, the T96S mutation status of GNAQ remained an independent prognostic marker for poor outcomes after adjusting for B symptoms, the International Prognostic Index (IPI), the Ki67 index (>50%), and the primary site of the tumor (OS: HR = 3.31, CI = 1.33–8.24, P = 0.010; and PFS: HR = 2.85, CI = 1.27–6.37, P = 0.011; Supplementary Table 12).