Taken together, it was considered that the lack of FGF5 expression in normal esophageal mucosa facilitated FGF5 methylation to creep into some esophageal cells, and that, when an ESCC happened to develop from such a cell with FGF5 methylation, the ESCC paradoxically showed sensitivity to dCRT. Here, FGF5 is linked to esophageal squamous cell carcinoma.