Although these observations aligns with other survival advantages provided by MTDH (e.g., enhanced EMT and drug resistance), such advantages are not gained without a price: due to the attenuation of system xc− function, MTDH-high cancers exhibit enhanced vulnerability to ferroptosis—a potential “Achilles” heel.” These observations also suggest a role for SLC3A2 in lipid peroxidation and ferroptosis, which is less known compared to its heterodimerization partner SLC7A11. This evidence concerns the gene MTDH and cancer.