In addition, MTDH can function as an effector of multiple epithelial–mesenchymal transition (EMT)-related microRNAs, and incorporate oncogenic signaling pathways such as phosphoinositide 3-kinase-AKT and Wnt/β-catenin to promote EMT, cancer stemness, and metastasis12,21–24. The gene discussed is MTDH; the disease is cancer.