In order to quantify marker expression at population level, percentage of HLA-A,B,C positive cells (A549) from a representative experiment were plotted on trajectories of radar plots among five different conditions: (I) 2D monolayer, (II) 3D Cytodex3, (III) 3D Nutrisphere, (IV) early and (V) late stage in vivo adenocarcinoma (Figure 8A). This evidence concerns the gene HLA-A and adenocarcinoma.