The following proteins determine trajectories within the pentagram to localize to advanced cancer (Figure 8): TRA-1-60 (9%), TMEM45A (37.5%), pan-keratin (50%), CD326 (100%), MCT4 (50%), GAL-3 (30%), CD66 (100%), GLUT1 (100%) (Figure 8A). This evidence concerns the gene TMEM45A and cancer.