TARDBP and Huntington disease: Similar to AD and PD, HD is characterised by aggregation of the polyglutamine expanded huntingtin (polyQ-Htt) protein [22], while ALS is characterised by mostly mutant TAR DNA-binding protein 43 (TDP-43) aggregation as well as superoxide dismutase 1 (SOD1) aggregation, although shared pathogeny between these ALS-linked proteins is still uncertain [12].