Moreover, 400 mg/kg C. butyricum intervention activated Toll-like receptor signaling pathway (Tlr2a/b), PI3K-Akt signaling pathway (Il10r-α/β), PPARs signaling pathway (Cyp7a1, Acsl1/5 and Ppar-γ), glycerophospholipid metabolism (Pla2g3), and cholesterol transporter activity (Abcg1 and Cetp) in the liver, which can improve immune function, promote fatty acid transportation, modulate cholesterol metabolism, and decrease lipid accumulation and fatty acid synthesis following CORT-induced liver injury. The gene discussed is AKT1; the disease is injury.