Dacomitinib (Figure 6A), a second generation irreversible inhibitor of EGFR-1, -2, and -4 tyrosine kinase, was approved for the treatment of NSCLC patients with EGFR mutations (EGFR exon 19 deletion or exon 21 L858R substitution mutations) [96]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.