LDHA and familial pancreatic carcinoma: FX-11, 3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid, is a selective, reversible, NADH competitive inhibitor of LDHA that has shown antitumor activity in lymphoma and pancreatic cancer xenografts [24,27,28].