HIF1A and neoplasm: The protective effect of CoCl2 on oxidative injury has been also reported in HepG2 tumor cells treated with tert-butyl hydroperoxide/serum deprivation [31], neonatal piglets that underwent hypothermic circulatory arrest [32], and in rats exposed to hypobaric hypoxia-induced oxidative stress [33], where the upregulation of HIF-1α and its target proteins play crucial roles for benefiting from CoCl2 preconditioning.