Several authors have suggested that the altered activity of the RNA Pol I is not caused by genetic alteration in the RNA Pol I, but mainly by the dysregulation of the major cancer-related signalling pathways like Myc, RAS/RAF/ERK, PI3K/AKT/mTOR, p53, pRb and PTEN [20,29,33,34]. Here, AKT1 is linked to cancer.