Further, some hnRNPs have been found to play a role in splicing, gene expression and metabolism across multiple cancer types, such as hnRNPK in cholangiocarcinoma [11], hnRNPI in colorectal cancer [13], hnRNPA1 and hnRNPAB in hepatocellular carcinoma [14, 15]. This evidence concerns the gene PTBP1 and cancer.