To address the specific function of TGF-β signaling in the neutrophil population of tumor-bearing mice, we transplanted KPN organoids into the colonic submucosa of syngeneic C57BL/6 mice lacking Alk5 expression specifically in Ly6G+ neutrophils (Ly6GCreAlk5fl/fl) (Figure 8E). This evidence concerns the gene TGFBR1 and neoplasm.