It was reported that cerebral ischemia and hypoxia could activate the Notch1 signaling pathway and four prominent interacting pathways (NF-κB, p53, HIF-1α and Pin1) that converge on a conserved DNA-associated nuclear multi-protein complex, which controls the expression of genes that could determine the fate of neurons. The gene discussed is NOTCH1; the disease is Cerebral ischemia.