Several possible mechanisms regarding immune-modulatory effects [181] through VEGF inhibition have been proposed, including T cell priming promotion and activation via DC maturation [181, 182], increased T cell tumor infiltration via normalization of the tumor vasculature through VEGF inhibition [183–185], and establishment of an immune-permissive TME via decreases in MDSC and Treg populations [181, 185]. Here, VEGFA is linked to neoplasm.