EGFR and non-small cell lung carcinoma: Specifically, in the phase I study of nivolumab (CheckMate 012), 21 EGFR-mutant NSCLC patients were treated with the combination of nivolumab and erlotinib associated with an acceptable toxicity profile, with a 15% ORR, 65% DCR, 5.1-month median PFS and 18.7-month median overall survival (OS) [30].