The ethnicity-stratified subgroup analysis showed that increased IL-18 level was associated with stroke in the Caucasian (case vs. control: SMD = 0.72, 95% CI = 0.12~1.31, p = 0.018) and Asian subgroups (case vs. control: SMD = 1.60, 95% CI = 0.24~2.96, p = 0.021) (Figure 4A). This evidence concerns the gene IL18 and Stroke.