Furthermore, in the subgroup analysis stratified by measurement method, high IL-18 level was associated with susceptibility to stroke in the ELISA subgroup (SMD = 1.02, 95% CI = 0.46~1.58, p< 0.001) but not the Luminex xMAP subgroup (p> 0.05) (Figure 4C). This evidence concerns the gene IL18 and stroke disorder.