IL18 and ischemic stroke: Analysis of the severity of disease demonstrated that IL-18 level in patients with mild, moderate and severe ischemic stroke was significantly higher than those in controls (mild: SMD = 1.74, 95% CI = 0.57 ~ 2.92, p = 0.004; moderate: SMD = 3.89, 95% CI = 1.72 ~ 6.06, p< 0.001; severe: SMD = 8.10, 95% CI = 4.40 ~ 11.80, p< 0.001) (Supplementary Figure 2).