WES of a further 366 HBM cases (240 isolated cases from the UK cohort with a total hip (TH) or L1Z‐score ≥+3.2 and 126 individuals from the Anglo‐Australasian Osteoporosis Genetics Consortium (AOGC)33 with either a total hip and/or lumbar spine (LS) Z‐score between +2.5 and +4.0) (Supplemental Fig. S2 in File S1) identified two individuals with the same SMAD9 c.65T>C, p.Leu22Pro variant. Here, SMAD9 is linked to osteoporosis.