The Borderline Leprosy (BL) group revealed a significant increase of the HLA-A variants (A3 or A11) compared to the healthy subjects (HS) (36.4% vs. 25.0%, P = 0.028, OR = 1.71, 95% CI = 1.08–2.71), even after multiple logistic regression (Adjusted OR = 2.24, P = 0.035). This evidence concerns the gene HLA-A and borderline leprosy.