Another study showed that unlike samples from healthy controls, LPS- and LPS + ATP-induced IL-1β secretion from whole-blood samples of genetically defined CAPS patients resisted MCC950/CRID3 inhibition [30], which is consistent with our results suggesting that MCC950/CRID3-based therapies may effectively treat inflammation driven by wild-type NLRP3 but may be markedly less effective in CAPS patients. Here, IL1B is linked to cryopyrin-associated periodic syndrome.