Aberrant NLRP3 inflammasome activity is thought to contribute to the pathogenesis of many chronic diseases, including inflammatory diseases such as gout and pseudogout; metabolic diseases like atherosclerosis and nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH); and neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis [10,11]. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.