The expression of OCT3 in CRC cell lines is higher than that of other organic cation transporters, and the higher the expression of OCT3 in CRC cell lines, the higher the concentration of OXA in the cells (7), suggesting that OCT3 may have a role in the uptake of OXA, although the results are contradictory (8). This evidence concerns the gene SLC22A3 and colorectal carcinoma.