TNF and endothelial dysfunction: Previous researches suggest that the pro-inflammatory cytokines such as IL-6, TNF-α, andIL-1β are considered as the central mediators for ruling the inflammatory biomarkers andoverproduction of these cytokines support the expansion of diabetes linked inflammation(Oliveira et al., 2008), coagulation (Silvaet al., 2017) and endothelial dysfunction(López-Bojórquez et al., 2004).