Several researchers suggest that the level of inflammatory cytokines was considerablyboosting during diabetes and a similar result was found in the current experimental study.Normal control group rats showed the normal level of inflammatory cytokines such as MCP-1(18.29 ± 1.83), IL-1β (15 ± 1.01), IL-1β (21.83 ± 1.85) and TNF-α (17.02 ± 1.03) and DMgroup rats showed the increased level of MCP-1 (236.94 ± 5.83), IL-1β (221.09 ± 5.12),IL-1β (255.2 ± 4.83) and TNF-α (271 ± 3.94), respectively. The gene discussed is CCL2; the disease is diabetes mellitus.