PGP and Hepatic fibrosis: Puerarin concentrations of the hepatic fibrosis group were significantly lower than those of the corresponding control group at almost any time after 5 mg/kg or 20 mg/kg intravenous administrated, which could attribute to the increased expression of P-gp, Ugt1a1, and Ugt1a7 in liver and intestines of hepatic fibrosis rats (Zhang et al., 2019).